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HPV E6 and Human papillomavirus oncogenes expression oncoproteins are the critical human papilloma virus kit in the process of malignant tumour formation.
Interacting with various cellular proteins, E6 and Human papilloma virus elisa kit influence fundamental cellular functions like cell cycle regulation, telomere maintenance, susceptibility to apoptosis, intercellular adhesion and regulation of immune responses. High-risk E6 and E7 bind to p53 and pRb and inactivate their functions with dysregulation of the cell cycle.
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All of the patient underwent colposcopy-guided biopsy to asses the grade of CIN. For the immunohistochemistry exam we used p16INK4A and Ki antibody and their expression was semiquantitatively classified in 4 classes: 0, 1, 2 and 3.
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